ผลของสารสกัดจากบัวบกที่มีต่อระบบหลอดเลือดและหัวใจ
ชื่อผู้แต่งข้างต้นเป็นข้อความจากระเบียนผลงาน ไม่ได้ผูกกับรหัสนักวิจัย จึงกดดูผลงานอื่นของบุคคลนี้ไม่ได้ — ในคลังนี้ 142,080 ผลงาน (63.6% ของทั้งหมด) มีชื่อผู้แต่งที่เชื่อมกับหน้าผู้แต่งได้ และ 60,298 ผลงาน (27.0%) มีผู้แต่งที่ผูกกับรหัสนักวิจัยจริง ส่วนอีก 81,382 ผลงานไม่มีข้อมูลผู้แต่งเลย (มีชื่อผู้แต่งเป็นข้อความอยู่ 142,009 ผลงาน = 63.5%)
บทคัดย่อ
Centella asiatica is one of the medicinal herbs that has been used extensively by Ayurvedic Pharmacoeia to alleviate high blood pressure. Therefore, use of this plant containing antihypertensive flavonoids (e.g. rutin, quercetin, and catechin) appeared a natural alternative for antihypertensive drugs replacement. Hence, the aims of the present study were to investigate the effects of Centella asiaticaextract and quercetin on rat aortic ring vasorelaxation activity in vitro and arterial blood pressure in male Wistar rats in vivo. This study consisted of 3 main experiments:Experiment 1 investigated the effects of Centella asiatica extract to elucidate the underlying mechanisms on isolated rat aortic rings using organ bath system. The results showed that Centella asiaticaextract had a yield of 8.04%. Total phenolic content was 87.47 ? 1.74 mg gallic acid/g dry extract. Centella asiatica extract and quercetin has a potential ability to regulate vascular tone. Vasorelaxation induced by Centella asiatica extract and quercetin were found to be endothelium-independent and unrelated to nitric oxide (NO). Opening of potassium (K+) channel and L-type calcium (Ca2+) channels was involved in the relaxation process of vascular smooth muscle. Experiment 2 investigated the acute effects of Centella asiatica extract on arterial blood pressure, heart rate, and respiratory rate of anaesthetized normotensive and NG-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats. The results showed blood pressure lowering effects of intragastric administration of Centella asiatica extract and quercetin in L-NAME induced hypertensive rats. Hypertensive effects of Centella asiatica extract and quercetin were found in normotensive rats. Centella asiatica extract and quercetin did not alter heart rate and respiratory rate in both groups.Experiment 3 investigated the sub-chronic effects of Centella asiatica extract and quercetin on systolic blood pressure (SBP) of normotensive and L-NAME induced hypertensive rats by the tail cuff method. The results showed that Centella asiatica extract and quercetin possessed antihypertensive effects on L-NAME induced hypertensive rats, but had no effect on normotensive rats.In conclusion, the present findings suggest that Centella asiatica extract and its bioactive compound quercetin exhibit antihypertensive effects and support traditional use of this plant in human cardiovascular diseases.