ผลของ curcumin ที่ช่วยลดภาวะแทรกซ้อนต่อการสะสมสาร Islet amyloid และการฟื้นฟูสภาพ Beta-cell ที่ตับอ่อนในภาวะเบาหวาน
ชื่อผู้แต่งข้างต้นเป็นข้อความจากระเบียนผลงาน ไม่ได้ผูกกับรหัสนักวิจัย จึงกดดูผลงานอื่นของบุคคลนี้ไม่ได้ — ในคลังนี้ 142,080 ผลงาน (63.6% ของทั้งหมด) มีชื่อผู้แต่งที่เชื่อมกับหน้าผู้แต่งได้ และ 60,298 ผลงาน (27.0%) มีผู้แต่งที่ผูกกับรหัสนักวิจัยจริง ส่วนอีก 81,382 ผลงานไม่มีข้อมูลผู้แต่งเลย (มีชื่อผู้แต่งเป็นข้อความอยู่ 142,009 ผลงาน = 63.5%)
บทคัดย่อ
Objective: To compare localization and expression of insulin and amylin in islets of Langerhans cells of pancreas in control group (C), diabetic group (DM) and diabetic supplemented with curcumin (DMC) by immunohistochemistry. Material and method: Diabetic rats were induced by streptozotocin injection (60 mg/kg BW). Three groups of male rats were performed and classified as control rat (C), diabetic rat (DM) and diabetic rat supplemented with curcumin (DMC) (200 mg/kg BW) respectively. At 8 weeks, animals were sacrificed. The localization and expression of insulin and amylin in islets of Langerhans cells were compared among C, DM and DMC groups by immunohistochemical techniques.Results: Type 1 Diabetes Mellitus (DM) is principally affected by the devastation of insulin-producing beta cells of the pancreas. Therefore, hyperglycemia is further a major factor, contributing to endothelial dysfunction and abnormalities in many body systems. Insulin therapy has been significantly used to control blood glucose level in diabetes. However, glycemic control and vascular complication are still problems in insulin-treated treatment. New approach of using another hormone from beta cells, amylin or islets amyloid polypeptide (IAPP) has been emerged to perfectively control glycemic condition. Amylin is actually co-produced and co-secreted with insulin. Curcumin, which is natural phenolic compound in turmeric, has potential effect to accelerate both insulin and amylin production and accumulation in islets of Langerhans of induced diabetic pancreas. Therefore, amylin might be an essential partner for insulin in order to control glycemic condition. Curcumin has significantly exhibited antioxidant anti-diabetic activities. It is implied that curcumin might recover diabetic pancreatic tissue, leading to produce both typical insulin and amylin. Conclusion: The potential effects of curcumin have been shown to enhance production and accumulation of insulin and amylin in islets of Langerhans cells in diabetic pancreas. Curcumin should be in focus as an alternative novel therapeutic agent in diabetes.